Albinism is a hereditary condition brought on by pretty much nothing or nonattendance of melanin in skin, hair and eyes, these leaves people with albinism pale and diverse contrasted with individuals from organic family. The objective of this study was to investigate the extent to which persons with albinism in East Africa region have been protected from discrimination. The study will be of a great assistance to education policies that are geared towards protection and creation of aware and understanding about persons with albinism in East African region. It also contribute to the body of knowledge on social stigma and explore self-esteem of persons living with albinism and perceived societal attitudes towards persons with albinism. The study was carried out using qualitative research methodology this involve the secondary use of data. The study goes further and critically analyze the myths and misconceptions surrounding persons with albinism in East African region, also discusses the nature of discrimination inflicted upon persons with albinism and finally outlines the legal and institutional frameworks at national and international levels to protect persons with albinism from discrimination. This study advocate for more effort to protect persons with albinism in east Africa since little have been done.